Detection of mechanical stimulus involved in sensory perception of sound

pathway activity — cross-omics
GO:0050910Cross-omicsPROTEIN-MS → RNACellPairwise association · TCGA cohorts

Across TCGA cell cohorts, RNA activity of the Detection of mechanical stimulus involved in sensory perception of sound pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLE4, GIT1, and UTP6, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of mechanical stimulus involved in sensory perception of sound activity versus TLE4 in LUNG_SCLC (Pearson r = 0.98).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUNG_SCLCTLE4 →+4.626+1.633.003<.00121
LUNG_SCLCGIT1 →+0.901+1.633.001<.00121
LUNG_SCLCUTP6 →+0.505+1.633.005<.00121
LUNG_SCLCMAPK10 →+1.055+1.633.009<.00121
LUNG_SCLCRALGPS2 →+3.270+1.633.002<.00121
LUNG_SCLCMTARC2 →+0.799+1.633.009<.00121
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050910 vs TLE4 — LUNG_SCLC

Per-sample scatter of Detection of mechanical stimulus involved in sensory perception of sound activity vs TLE4 in LUNG_SCLC.

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Exploration