Sensory perception of taste

Across TCGA cell cohorts, RNA activity of the Sensory perception of taste pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2AZ2, RTP4, and DYNC2H1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H2AZ2 grouped by Sensory perception of taste-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	H2AZ2 →	-0.384	-1.636	.002	<.001	3	8
CNS	RTP4 →	-0.151	-1.016	.002	.004	3	8
CNS	DYNC2H1 →	-0.294	-0.864	.002	.007	2	8
CNS	ITPR3 →	-0.271	-0.987	<.001	<.001	3	5
LUNG_NSCLC_LUSC	IFNA10 →	-0.442	-1.572	.002	.002	3	5
CNS	SLC25A1 →	-0.318	-1.187	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H2AZ2 by Sensory perception of taste activity — PANCREAS

Explore this box plot interactively →