Neuromuscular process

Across TCGA cell cohorts, RNA activity of the Neuromuscular process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC4A1, USP33, and VKORC1L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC4A1 grouped by Neuromuscular process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLC4A1 →	+0.301	+0.178	.001	.001	3	4
PANCREAS	USP33 →	+0.111	+0.136	<.001	.008	3	4
LUNG_SCLC	VKORC1L1 →	-0.286	-0.166	.004	.007	2	5
LUNG_NSCLC_LUAD	IQCF1 →	-0.097	-0.569	.008	.005	3	4
SKIN	GPR65 →	-0.162	-0.743	<.001	.005	3	3
BONE	COPS3 →	-0.601	-1.140	.005	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC4A1 by Neuromuscular process activity — LUNG_SCLC

Explore this box plot interactively →