Neuromuscular process

Across TCGA cell cohorts, RNA activity of the Neuromuscular process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPAG1, MPP5, and EBF4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPAG1 grouped by Neuromuscular process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SPAG1 →	+0.844	+0.171	.007	.003	3	3
PANCREAS	MPP5 →	+1.141	+0.273	.001	<.001	3	3
PANCREAS	EBF4 →	-1.193	-0.205	.001	.003	3	3
LARGE_INTESTINE	QPRT →	+2.950	+0.213	.004	<.001	3	3
KIDNEY	FZD3 →	-0.886	-1.306	<.001	<.001	3	3
OESOPHAGUS	ZNF91 →	+1.443	+0.236	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPAG1 by Neuromuscular process activity — PANCREAS

Explore this box plot interactively →