Diapedesis

Across TCGA patient cohorts, RNA activity of the Diapedesis pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAB1, SCRIB, and VIM, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diapedesis activity versus STAB1 in LUAD (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	STAB1 →	+0.371	+0.065	<.001	<.001	3	9
COAD	SCRIB →	-0.346	-0.049	<.001	<.001	3	8
COAD	VIM →	+0.455	+0.049	<.001	<.001	3	8
HNSC	WIPF1 →	+0.410	+0.075	<.001	<.001	3	8
BRCA	FERMT2 →	+0.489	+0.027	<.001	<.001	3	8
HNSC	HCLS1 →	+0.400	+0.044	<.001	.007	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050904 vs STAB1 — LUAD

Explore this scatter interactively →