Diapedesis

Across TCGA cell cohorts, RNA activity of the Diapedesis pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL22, HNRNPA1P10, and TREML1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPL22 grouped by Diapedesis-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RPL22 →	+0.148	+1.447	<.001	<.001	3	4
STOMACH	HNRNPA1P10 →	+0.248	+0.944	<.001	.007	3	3
URINARY_TRACT	TREML1 →	+0.212	+1.703	.005	<.001	2	4
SOFT_TISSUE	RXYLT1 →	+0.330	+1.520	.001	.001	3	3
SOFT_TISSUE	KLF12 →	+0.262	+1.083	<.001	.001	3	3
SOFT_TISSUE	UCK2 →	-0.367	-1.530	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPL22 by Diapedesis activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →