Diapedesis

Across TCGA cell cohorts, RNA activity of the Diapedesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA4, CERKL, and FER, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diapedesis activity versus ITGA4 in LUNG_SCLC (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ITGA4 →	+3.065	+0.874	<.001	.006	2	13
SOFT_TISSUE	CERKL →	+1.856	+1.094	<.001	<.001	3	12
STOMACH	FER →	+1.818	+1.015	<.001	.001	2	12
BONE	GPR176 →	+3.111	+1.369	<.001	<.001	3	9
BONE	DPYD →	+2.463	+1.309	<.001	<.001	3	9
BONE	EXD3 →	-0.726	-0.781	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050904 vs ITGA4 — LUNG_SCLC

Explore this scatter interactively →