Multicellular organismal-level water homeostasis

Across TCGA cell cohorts, RNA activity of the Multicellular organismal-level water homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED7, SLC35G2, and LST1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multicellular organismal-level water homeostasis activity versus TMED7 in OVARY (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TMED7 →	+0.659	+0.270	.005	.009	3	6
UPPER_AERODIGESTIVE_TRACT	SLC35G2 →	+1.737	+0.880	<.001	.001	3	4
BLOOD_Leukemia	LST1 →	-3.045	-0.811	.002	.001	3	4
BONE	EID1 →	+0.603	+0.285	.007	.002	3	4
STOMACH	TMEM64 →	+1.500	+0.319	.007	<.001	2	5
OVARY	RFFL →	+0.773	+0.254	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050891 vs TMED7 — OVARY

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