Endocrine process

Across TCGA patient cohorts, RNA activity of the Endocrine process pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCDH12, MYCT1, and DIPK2B, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocrine process activity versus PCDH12 in TGCT (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	PCDH12 →	+1.078	+0.021	<.001	<.001	3	28
KIRC	MYCT1 →	+1.159	+0.035	<.001	<.001	3	28
KIRC	DIPK2B →	+1.129	+0.038	<.001	<.001	3	28
KIRC	ADGRL4 →	+1.194	+0.036	<.001	<.001	3	28
CHOL	TM4SF18 →	+1.578	+0.023	.001	<.001	2	29
KIRC	ARHGEF15 →	+1.022	+0.036	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050886 vs PCDH12 — TGCT

Explore this scatter interactively →