Endocrine process

Across TCGA cell cohorts, RNA activity of the Endocrine process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEF2D, TMEM255B, and ZNFX1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MEF2D grouped by Endocrine process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MEF2D →	-1.031	-0.930	.003	.001	3	5
BONE	TMEM255B →	-2.441	-1.440	.001	<.001	3	5
LARGE_INTESTINE	ZNFX1 →	-0.987	-0.871	.001	<.001	3	4
CNS	SFXN3 →	-0.605	-0.876	.001	.002	3	4
LUNG_SCLC	CHCHD2 →	-0.625	-1.387	.002	.001	3	4
LUNG_NSCLC_LUAD	LTC4S →	+0.445	+0.654	.009	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MEF2D by Endocrine process activity — LARGE_INTESTINE

Explore this box plot interactively →