Endocrine process

Across TCGA cell cohorts, RNA activity of the Endocrine process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FNDC3B, CYP2D6, and BABAM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocrine process activity versus FNDC3B in BLOOD_Leukemia (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FNDC3B →	+1.322	+0.522	<.001	.005	3	5
URINARY_TRACT	CYP2D6 →	-0.654	-0.218	.009	.006	3	4
BLOOD_Lymphoma	BABAM2 →	+0.919	+1.225	.001	<.001	3	4
SOFT_TISSUE	ARL5B →	-0.862	-0.313	.003	.005	3	4
LUNG_NSCLC_LUSC	PRR15 →	-4.120	-0.431	.007	.003	3	4
BLOOD_Leukemia	GPR63 →	-1.295	-0.838	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050886 vs FNDC3B — BLOOD_Leukemia

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