Neuromuscular process controlling balance

Across TCGA patient cohorts, RNA activity of the Neuromuscular process controlling balance pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLOD1, MPO, and TACC2_S473, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuromuscular process controlling balance activity versus PLOD1 in PDAC (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PLOD1 →	+0.411	+0.025	<.001	.002	3	6
PDAC	MPO →	+1.116	+0.032	<.001	.001	3	5
LSCC	TACC2_S473 →	-0.860	-0.041	.003	<.001	3	5
LSCC	MMP9 →	+0.740	+0.039	<.001	<.001	3	5
LUAD	PLOD2 →	+0.745	+0.041	.002	.007	3	5
LSCC	TNFRSF12A →	+0.707	+0.043	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050885 vs PLOD1 — PDAC

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