Neuromuscular process controlling balance

Across TCGA patient cohorts, RNA activity of the Neuromuscular process controlling balance pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIAPH3-AS1, SNX6, and THOC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuromuscular process controlling balance activity versus DIAPH3-AS1 in UCEC (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DIAPH3-AS1 →	-0.503	-0.095	.006	.005	3	4
GBM	SNX6 →	-0.241	-0.160	.003	.008	3	4
PDAC	THOC1 →	-0.240	-0.186	.009	.002	3	4
HNSC	INPP4B →	+0.749	+0.158	<.001	<.001	3	3
COAD	SLC25A21 →	-0.430	-0.109	.008	.009	3	3
COAD	ELF3-AS1 →	+0.334	+0.081	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050885 vs DIAPH3-AS1 — UCEC

Explore this scatter interactively →