Neuromuscular process controlling balance

Across TCGA cell cohorts, RNA activity of the Neuromuscular process controlling balance pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAP1A, KIF20A, and VXN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAP1A grouped by Neuromuscular process controlling balance-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RAP1A →	+1.279	+1.620	.002	<.001	3	4
SOFT_TISSUE	KIF20A →	+0.956	+2.012	.002	<.001	3	4
SKIN	VXN →	-0.971	-0.902	<.001	.001	3	4
SKIN	WDR53 →	+0.450	+1.168	.003	.002	3	4
OVARY	PRDM5 →	+0.926	+0.938	.009	.003	3	4
BONE	SYTL3 →	+1.695	+1.620	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAP1A by Neuromuscular process controlling balance activity — BONE

Explore this box plot interactively →