Neuromuscular process controlling balance

Across TCGA cell cohorts, RNA activity of the Neuromuscular process controlling balance pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POMK, GOLPH3, and FBXW2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuromuscular process controlling balance activity versus POMK in SKIN (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	POMK →	+0.745	+0.161	.001	<.001	3	5
LUNG_SCLC	GOLPH3 →	+0.566	+0.201	.002	.007	3	4
LUNG_SCLC	FBXW2 →	+0.774	+0.307	<.001	.001	3	4
SKIN	NPLOC4 →	+0.916	+0.250	.003	.001	3	4
LARGE_INTESTINE	MT-CYB →	+0.969	+0.293	.003	.004	3	3
LUNG_SCLC	TM9SF1 →	+0.719	+0.243	.004	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050885 vs POMK — SKIN

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