Voluntary musculoskeletal movement

Across TCGA patient cohorts, RNA activity of the Voluntary musculoskeletal movement pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EVL, GIMAP4, and RLF_S632, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Voluntary musculoskeletal movement activity versus EVL in CCRCC (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	EVL →	+0.464	+0.049	<.001	<.001	2	8
GBM	GIMAP4 →	+0.494	+0.049	<.001	<.001	3	7
BRCA	RLF_S632 →	-0.969	-0.060	.001	.005	3	7
BRCA	SH3BGRL →	+0.472	+0.051	<.001	<.001	3	7
HNSC	SNX2 →	+0.194	+0.076	.003	.003	3	7
UCEC	TNS1_S445 →	+1.288	+0.064	.005	.009	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050882 vs EVL — CCRCC

Explore this scatter interactively →