Voluntary musculoskeletal movement

Across TCGA patient cohorts, RNA activity of the Voluntary musculoskeletal movement pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBN1, MAP1A, and MEIS3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Voluntary musculoskeletal movement activity versus FBN1 in OV (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FBN1 →	+1.166	+0.600	.008	.003	3	8
HNSC	MAP1A →	+1.196	+1.162	<.001	<.001	3	8
OV	MEIS3 →	+1.081	+0.562	<.001	.002	3	7
OV	DACT3 →	+0.671	+0.492	<.001	.004	3	7
OV	AEBP1 →	+1.644	+0.591	<.001	.001	3	6
OV	TGFB3 →	+1.073	+0.481	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050882 vs FBN1 — OV

Explore this scatter interactively →