Voluntary musculoskeletal movement

Across TCGA cell cohorts, RNA activity of the Voluntary musculoskeletal movement pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBAC2, RAB30, and CDS1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Voluntary musculoskeletal movement activity versus UBAC2 in BLOOD_Leukemia (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UBAC2 →	-0.646	-0.323	.005	.003	3	2
CNS	RAB30 →	+2.230	+0.679	.001	.005	3	1
CNS	CDS1 →	+1.129	+0.709	.009	.003	3	1
CNS	DTX3L →	+1.656	+0.679	.005	.005	3	1
CNS	HS6ST3 →	+1.540	+0.676	.005	.006	3	1
CNS	C20orf202 →	+0.126	+0.660	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050882 vs UBAC2 — BLOOD_Leukemia

Explore this scatter interactively →