Multicellular organismal movement

Across TCGA patient cohorts, RNA activity of the Multicellular organismal movement pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1A, ZCCHC24, and ZEB2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multicellular organismal movement activity versus MAP1A in UCEC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAP1A →	+0.950	+0.489	<.001	.004	3	8
OV	ZCCHC24 →	+1.215	+0.659	<.001	.004	3	7
OV	ZEB2 →	+0.781	+0.641	<.001	.003	3	7
GBM	LMOD1 →	+0.955	+0.387	<.001	<.001	3	7
GBM	MYLK →	+0.705	+0.259	<.001	<.001	3	7
OV	CRISPLD2 →	+1.135	+0.533	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050879 vs MAP1A — UCEC

Explore this scatter interactively →