Multicellular organismal movement

Across TCGA cell cohorts, RNA activity of the Multicellular organismal movement pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAA, CPNE2, and SEPTIN5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multicellular organismal movement activity versus GAA in OVARY (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GAA →	+1.001	+0.207	<.001	<.001	3	5
BLOOD_Leukemia	CPNE2 →	+1.347	+0.162	.003	.001	3	5
UPPER_AERODIGESTIVE_TRACT	SEPTIN5 →	+1.427	+0.264	.003	.001	3	4
OESOPHAGUS	CCDC173 →	+0.132	+0.235	.006	.001	3	4
URINARY_TRACT	DENND6B →	+1.029	+0.490	.002	.004	3	4
SOFT_TISSUE	UQCC1 →	-0.655	-0.279	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050879 vs GAA — OVARY

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