Brown fat cell differentiation

Across TCGA patient cohorts, RNA activity of the Brown fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSP, AGAP2, and TIMD4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Brown fat cell differentiation activity versus DSP in LUAD (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DSP →	+1.240	+0.177	<.001	.001	3	5
PDAC	AGAP2 →	-0.407	-0.571	<.001	<.001	3	3
PDAC	TIMD4 →	-0.994	-0.482	<.001	.005	3	3
PDAC	PPIAP84 →	-0.104	-0.518	.007	<.001	3	3
LSCC	MIR548K →	+0.990	+0.411	.001	.001	3	3
CCRCC	ILF3 →	+0.201	+0.588	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050873 vs DSP — LUAD

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