Brown fat cell differentiation

Across TCGA cell cohorts, RNA activity of the Brown fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NELL2, S100A3, and CCDC14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NELL2 grouped by Brown fat cell differentiation-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NELL2 →	+5.186	+0.473	.001	.005	3	4
OVARY	S100A3 →	-1.164	-0.780	.002	.005	3	4
SKIN	CCDC14 →	-0.499	-0.859	.003	.002	3	3
BONE	SATL1 →	+0.371	+0.288	<.001	.009	3	3
STOMACH	CD68 →	-2.679	-0.864	.009	.002	3	3
KIDNEY	TRIM36 →	-0.737	-1.038	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NELL2 by Brown fat cell differentiation activity — BLOOD_Lymphoma

Explore this box plot interactively →