Brown fat cell differentiation

Across TCGA cell cohorts, RNA activity of the Brown fat cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP27P1-BPTFP1-KPNA2P3, DDX25, and CERT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGAP27P1-BPTFP1-KPNA2P3 grouped by Brown fat cell differentiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARHGAP27P1-BPTFP1-KPNA2P3 →	-0.454	-0.181	.001	<.001	3	5
OESOPHAGUS	DDX25 →	+0.129	+0.155	.008	.007	2	5
OVARY	CERT1 →	+0.182	+0.183	<.001	<.001	3	4
CNS	DYNLL2 →	+0.192	+0.105	<.001	.002	3	4
BREAST	SPRED1 →	-0.142	-0.178	<.001	<.001	3	4
SOFT_TISSUE	DYNAP →	+0.236	+0.259	.003	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGAP27P1-BPTFP1-KPNA2P3 by Brown fat cell differentiation activity — LARGE_INTESTINE

Explore this box plot interactively →