Brown fat cell differentiation

Across TCGA cell cohorts, RNA activity of the Brown fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED3, TOMM40L, and P4HB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Brown fat cell differentiation activity versus TMED3 in BLOOD_Leukemia (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMED3 →	-0.727	-0.987	<.001	<.001	3	5
SKIN	TOMM40L →	-0.615	-0.810	.001	.002	3	5
SKIN	P4HB →	-0.693	-1.109	.001	.001	3	5
BLOOD_Leukemia	QDPR →	-0.634	-0.827	.007	.008	2	5
LUNG_NSCLC_LUAD	PRR13 →	-0.745	-1.190	.001	<.001	3	4
BREAST	RCAN1 →	-1.930	-0.871	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050873 vs TMED3 — BLOOD_Leukemia

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