White fat cell differentiation

Across TCGA patient cohorts, RNA activity of the White fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRB, ZNF25, and SENP7, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, White fat cell differentiation activity versus PTPRB in CHOL (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	PTPRB →	+1.435	+0.083	<.001	<.001	3	27
UVM	ZNF25 →	+1.041	+0.035	<.001	<.001	3	26
THYM	SENP7 →	+0.987	+0.054	<.001	<.001	3	26
KIRC	PREX2 →	+0.870	+0.035	<.001	<.001	3	25
MESO	KLF9 →	+1.423	+0.060	<.001	<.001	3	25
CHOL	TAL1 →	+0.875	+0.049	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050872 vs PTPRB — CHOL

Explore this scatter interactively →