White fat cell differentiation

Across TCGA patient cohorts, RNA activity of the White fat cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD36, TNS2_S120, and MYO1C, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, White fat cell differentiation activity versus CD36 in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD36 →	+1.064	+0.043	<.001	<.001	3	8
BRCA	TNS2_S120 →	+0.777	+0.076	<.001	<.001	3	7
OV	MYO1C →	+0.745	+0.065	<.001	<.001	3	7
BRCA	RPL5 →	-0.309	-0.067	<.001	<.001	3	7
PDAC	EIF2S3 →	-0.177	-0.044	<.001	.004	3	7
OV	ADIPOQ →	+0.795	+0.052	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050872 vs CD36 — BRCA

Explore this scatter interactively →