White fat cell differentiation

Across TCGA cell cohorts, RNA activity of the White fat cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBL1XR1, KTN1, and RAB11FIP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBL1XR1 grouped by White fat cell differentiation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TBL1XR1 →	-0.307	-1.194	<.001	<.001	3	8
CNS	KTN1 →	-0.171	-0.664	.001	.002	3	5
KIDNEY	RAB11FIP2 →	+0.273	+0.296	.001	.001	3	4
OESOPHAGUS	ADRA1D →	-0.303	-1.158	.004	.009	3	4
LIVER	RBPJL →	+0.190	+1.570	.004	.002	3	4
BREAST	LY6G6C →	-0.214	-0.921	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBL1XR1 by White fat cell differentiation activity — STOMACH

Explore this box plot interactively →