White fat cell differentiation

Across TCGA cell cohorts, RNA activity of the White fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF264, CCR9, and MAP4K5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF264 grouped by White fat cell differentiation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ZNF264 →	-0.850	-1.254	.004	<.001	3	4
OESOPHAGUS	CCR9 →	-0.020	-1.080	.001	<.001	3	4
SOFT_TISSUE	MAP4K5 →	-0.682	-1.110	.004	<.001	3	4
SOFT_TISSUE	TTC7A →	-1.334	-1.072	.005	.004	3	4
SOFT_TISSUE	MARK3 →	-1.166	-1.405	<.001	<.001	3	4
STOMACH	EEF2KMT →	+0.697	+1.186	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF264 by White fat cell differentiation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →