Positive regulation of B cell activation

Across TCGA patient cohorts, RNA activity of the Positive regulation of B cell activation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL2RB, IFNG, and GPR174, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of B cell activation activity versus IL2RB in HNSC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IL2RB →	+0.733	+0.783	.006	.001	2	7
BRCA	IFNG →	+0.854	+0.821	.001	<.001	3	5
HNSC	GPR174 →	+1.016	+1.028	<.001	<.001	3	5
LSCC	CCR5 →	+0.495	+0.266	.002	.008	2	6
LUAD	CD7 →	+0.734	+0.152	.001	.007	3	5
LSCC	NCR3 →	+0.391	+0.243	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050871 vs IL2RB — HNSC

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