Positive regulation of B cell activation

Across TCGA patient cohorts, RNA activity of the Positive regulation of B cell activation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PIK3AP1, STK4, and FYB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of B cell activation activity versus PIK3AP1 in HNSC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PIK3AP1 →	+0.562	+1.154	<.001	<.001	3	6
CCRCC	STK4 →	+0.328	+0.905	<.001	.001	3	5
HNSC	FYB1 →	+0.575	+0.885	<.001	<.001	3	5
LUAD	IKZF1_S63 →	+0.603	+0.197	<.001	.001	3	5
GBM	LCP2 →	+0.774	+0.674	<.001	.001	2	6
GBM	RELB →	+0.507	+0.644	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050871 vs PIK3AP1 — HNSC

Explore this scatter interactively →