Positive regulation of B cell activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of B cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP4K3, NFKBID, and ZSCAN16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP4K3 grouped by Positive regulation of B cell activation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MAP4K3 →	+1.016	+0.214	<.001	.001	3	4
OESOPHAGUS	NFKBID →	+1.070	+0.163	.001	.006	3	4
BLOOD_Lymphoma	ZSCAN16 →	+1.635	+0.465	.005	<.001	3	4
BLOOD_Myeloma	SYNC →	-0.088	-0.277	.001	<.001	3	3
BLOOD_Myeloma	ASPH →	+1.424	+0.198	.001	.004	3	3
LIVER	CDKN2A →	+4.101	+0.255	.007	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP4K3 by Positive regulation of B cell activation activity — BLOOD_Myeloma

Explore this box plot interactively →