Positive regulation of B cell activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of B cell activation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIPE, SLC22A17, and H2BC12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of B cell activation activity versus LIPE in LUNG_NSCLC_LUAD (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LIPE →	-1.465	-0.221	<.001	<.001	3	4
LUNG_NSCLC_LUAD	SLC22A17 →	+1.997	+0.206	<.001	<.001	3	4
BLOOD_Myeloma	H2BC12 →	+2.163	+0.314	<.001	<.001	3	4
BLOOD_Myeloma	LTBP1 →	+3.200	+0.318	.006	<.001	3	4
BLOOD_Myeloma	ATP5F1D →	-0.912	-0.342	.001	.001	3	4
LUNG_NSCLC_LUAD	COCH →	-1.520	-0.131	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050871 vs LIPE — LUNG_NSCLC_LUAD

Explore this scatter interactively →