Negative regulation of B cell activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of B cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TM9SF2, SDHAF3, and CCDC34, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TM9SF2 grouped by Negative regulation of B cell activation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TM9SF2 →	-0.963	-1.438	<.001	.002	2	5
LARGE_INTESTINE	SDHAF3 →	+1.251	+1.262	<.001	<.001	3	4
KIDNEY	CCDC34 →	+0.739	+1.095	<.001	<.001	3	4
KIDNEY	ESPL1 →	+0.992	+1.270	.006	.001	3	4
URINARY_TRACT	RELA →	+0.877	+1.689	.006	<.001	3	4
BONE	TUBGCP4 →	+0.870	+1.756	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TM9SF2 by Negative regulation of B cell activation activity — BLOOD_Myeloma

Explore this box plot interactively →