Negative regulation of B cell activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of B cell activation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCRLA, CCN3, and ADGRG7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FCRLA grouped by Negative regulation of B cell activation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FCRLA →	+0.216	+0.146	<.001	.001	3	4
BREAST	CCN3 →	+0.190	+0.147	.008	.005	3	4
LUNG_SCLC	ADGRG7 →	-0.145	-0.141	.007	.005	2	5
BREAST	GBX1 →	+0.170	+0.133	.001	.009	3	4
SKIN	SEMA3G →	-0.149	-0.129	.003	.006	3	4
SKIN	BIN1 →	-0.091	-0.103	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FCRLA by Negative regulation of B cell activation activity — BREAST

Explore this box plot interactively →