Negative regulation of B cell activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of B cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DENND1B, C1orf167, and CERS4, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of B cell activation activity versus DENND1B in BLOOD_Lymphoma (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DENND1B →	-1.053	-1.294	.007	<.001	3	2
BLOOD_Lymphoma	C1orf167 →	+2.188	+1.454	.005	<.001	3	2
BLOOD_Lymphoma	CERS4 →	-1.185	-1.638	.002	<.001	3	2
BLOOD_Lymphoma	HPS4 →	+1.511	+1.071	.004	.006	3	1
BLOOD_Lymphoma	KCTD17 →	+1.432	+1.113	.001	.004	3	1
BLOOD_Lymphoma	PLA2G15 →	+1.913	+1.454	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050869 vs DENND1B — BLOOD_Lymphoma

Explore this scatter interactively →