Negative regulation of cell activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell activation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJB5, WSB2, and NEK1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell activation activity versus DNAJB5 in OVARY (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DNAJB5 →	+0.910	+0.242	.009	.003	3	7
BLOOD_Lymphoma	WSB2 →	+1.884	+0.220	.001	.003	3	7
CNS	NEK1 →	+0.823	+0.285	<.001	.005	3	6
URINARY_TRACT	EPCAM →	-4.693	-0.592	.008	.003	3	6
OVARY	SEC22C →	+0.766	+0.283	.002	.001	3	6
LUNG_NSCLC_LUSC	ZEB1 →	+3.560	+0.333	<.001	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050866 vs DNAJB5 — OVARY

Explore this scatter interactively →