Regulation of B cell activation

Across TCGA patient cohorts, RNA activity of the Regulation of B cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL21R, SEMA7A, and CXCL9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of B cell activation activity versus IL21R in BRCA (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IL21R →	+0.768	+0.687	.005	.006	3	4
BRCA	SEMA7A →	+0.854	+0.966	<.001	<.001	3	4
COAD	CXCL9 →	+1.565	+0.819	.003	.001	3	4
COAD	APOBEC3G →	+0.728	+0.691	.007	.007	3	4
CCRCC	LYN →	+0.530	+0.849	<.001	.001	3	4
BRCA	CD4 →	+0.617	+0.629	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050864 vs IL21R — BRCA

Explore this scatter interactively →