Regulation of B cell activation

Across TCGA cell cohorts, RNA activity of the Regulation of B cell activation pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHX35, TP53BP1, and MREG, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHX35 grouped by Regulation of B cell activation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DHX35 →	-0.177	-0.353	<.001	.005	3	5
LUNG_SCLC	TP53BP1 →	-0.213	-0.186	<.001	<.001	3	5
SKIN	MREG →	-0.150	-0.472	<.001	.005	3	5
STOMACH	CDKN1A →	-0.270	-0.180	.002	<.001	3	5
STOMACH	LCN2 →	+0.140	+0.213	.003	.001	3	4
OESOPHAGUS	REPIN1 →	-0.187	-0.123	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHX35 by Regulation of B cell activation activity — CNS

Explore this box plot interactively →