Regulation of B cell activation

Across TCGA cell cohorts, RNA activity of the Regulation of B cell activation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLCA2, TMEM126B, and SH2D2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of B cell activation activity versus CLCA2 in URINARY_TRACT (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CLCA2 →	+1.755	+0.264	.009	.002	3	4
UPPER_AERODIGESTIVE_TRACT	TMEM126B →	-1.155	-0.341	.001	.002	3	4
SKIN	SH2D2A →	-0.957	-0.156	.005	.004	3	4
BLOOD_Myeloma	VPS18 →	+1.072	+0.281	.006	.004	3	4
STOMACH	UNK →	+0.773	+0.222	.006	<.001	3	4
STOMACH	SLC45A3 →	-1.744	-0.262	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050864 vs CLCA2 — URINARY_TRACT

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