Positive regulation of B cell receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of B cell receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CSK, EVL, and ITPR1_S1764, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of B cell receptor signaling pathway activity versus CSK in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CSK →	+0.281	+0.032	<.001	<.001	3	9
LSCC	EVL →	+0.675	+0.139	<.001	<.001	3	9
LSCC	ITPR1_S1764 →	+0.572	+0.112	<.001	<.001	3	9
LSCC	PRKCH_S317 →	+0.538	+0.085	<.001	<.001	3	8
LSCC	RASSF2 →	+0.477	+0.114	<.001	<.001	3	8
LSCC	RCSD1 →	+0.654	+0.127	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050861 vs CSK — BRCA

Explore this scatter interactively →