Positive regulation of B cell receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of B cell receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHYHD1, PITPNA, and GCA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHYHD1 grouped by Positive regulation of B cell receptor signaling pathway-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PHYHD1 →	-0.302	-0.113	<.001	.002	3	4
BLOOD_Lymphoma	PITPNA →	+0.284	+0.111	.001	.006	3	3
SOFT_TISSUE	GCA →	-0.269	-0.471	.004	<.001	3	3
SOFT_TISSUE	ANKRD60 →	-0.192	-0.351	<.001	<.001	3	3
SOFT_TISSUE	SLC2A11 →	-0.287	-0.359	<.001	<.001	3	3
SOFT_TISSUE	NEK3 →	+0.181	+0.403	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHYHD1 by Positive regulation of B cell receptor signaling pathway activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →