Negative regulation of T cell receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of T cell receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFAIP3, EGFLAM, and WAKMAR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T cell receptor signaling pathway activity versus TNFAIP3 in BRCA (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TNFAIP3 →	+0.811	+0.102	.001	.009	3	3
CCRCC	EGFLAM →	+0.807	+0.186	<.001	<.001	3	3
BRCA	WAKMAR2 →	+0.459	+0.100	<.001	.007	2	4
GBM	IKBKG →	+0.160	+0.322	.004	.004	3	3
UCEC	SIX2 →	+0.752	+0.165	<.001	.003	3	3
BRCA	SLA2 →	+0.588	+0.092	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050860 vs TNFAIP3 — BRCA

Explore this scatter interactively →