Negative regulation of B cell receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of B cell receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HCLS1, ARHGEF6, and WIPF1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of B cell receptor signaling pathway activity versus HCLS1 in GBM (Pearson r = 0.80).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HCLS1 →	+0.670	+0.130	<.001	<.001	3	10
LSCC	ARHGEF6 →	+0.584	+0.196	<.001	<.001	3	10
LSCC	WIPF1 →	+0.455	+0.183	<.001	<.001	3	9
LSCC	DOCK10_T1440 →	+0.923	+0.161	<.001	<.001	3	9
LSCC	EVL →	+0.704	+0.187	<.001	<.001	3	9
LSCC	FMNL1 →	+0.644	+0.176	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050859 vs HCLS1 — GBM

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