Negative regulation of B cell receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of B cell receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAOK3, POLD4, and SMIM10L1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of B cell receptor signaling pathway activity versus TAOK3 in BLOOD_Leukemia (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TAOK3 →	+0.982	+0.742	.004	.004	3	3
BLOOD_Lymphoma	POLD4 →	+2.032	+1.387	<.001	.002	3	3
BLOOD_Lymphoma	SMIM10L1 →	-0.886	-1.232	.001	.006	3	3
BLOOD_Lymphoma	CNR2 →	+2.127	+1.614	<.001	<.001	3	2
BLOOD_Lymphoma	SEMA4A →	+2.699	+1.303	.004	.001	3	2
BLOOD_Lymphoma	POU2F2 →	+4.092	+1.453	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050859 vs TAOK3 — BLOOD_Leukemia

Explore this scatter interactively →