Positive regulation of antigen receptor-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of antigen receptor-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SASH3, STK10, and WAS, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of antigen receptor-mediated signaling pathway activity versus SASH3 in LSCC (Pearson r = 0.84).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SASH3 →	+0.537	+0.118	<.001	<.001	3	10
LSCC	STK10 →	+0.469	+0.115	<.001	<.001	3	10
GBM	WAS →	+0.567	+0.070	<.001	<.001	3	10
LSCC	WDFY4 →	+0.619	+0.124	<.001	<.001	3	10
CCRCC	ADA2 →	+0.635	+0.075	<.001	<.001	3	10
LSCC	BTK →	+0.666	+0.111	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050857 vs SASH3 — LSCC

Explore this scatter interactively →