Positive regulation of antigen receptor-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of antigen receptor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TESPA1, LINC00426, and LINC02325, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of antigen receptor-mediated signaling pathway activity versus TESPA1 in LSCC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TESPA1 →	+0.852	+0.382	<.001	<.001	3	6
LSCC	LINC00426 →	+0.478	+0.344	<.001	<.001	3	6
LSCC	LINC02325 →	+0.242	+0.294	<.001	<.001	3	6
LSCC	ARHGAP9 →	+0.518	+0.359	<.001	<.001	3	5
LSCC	STAT4 →	+0.757	+0.367	<.001	<.001	3	5
CCRCC	GPR174 →	+0.810	+0.375	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050857 vs TESPA1 — LSCC

Explore this scatter interactively →