Positive regulation of antigen receptor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of antigen receptor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GABARAPL1, CYP39A1, and MACROH2A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of antigen receptor-mediated signaling pathway activity versus GABARAPL1 in STOMACH (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GABARAPL1 →	+2.021	+1.233	.004	<.001	3	5
BONE	CYP39A1 →	+1.146	+1.628	<.001	.002	3	5
LUNG_NSCLC_LUAD	MACROH2A2 →	+1.735	+0.901	.009	.003	3	4
BONE	RAB32 →	+4.162	+1.571	.008	.009	3	4
OVARY	CLU →	+2.585	+1.009	.001	<.001	3	4
BONE	HOXA1 →	+1.945	+1.844	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050857 vs GABARAPL1 — STOMACH

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