Regulation of T cell receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of T cell receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYTH4, GPR132, and FMNL1, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell receptor signaling pathway activity versus CYTH4 in LAML (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	CYTH4 →	+1.698	+0.066	<.001	<.001	3	29
CHOL	GPR132 →	+1.351	+0.038	<.001	.004	3	29
SKCM	FMNL1 →	+1.289	+0.054	<.001	<.001	3	29
DLBC	GIMAP4 →	+1.891	+0.074	<.001	<.001	3	28
SKCM	MYO1F →	+1.264	+0.056	<.001	<.001	3	28
SCLC	CSF2RB →	+1.551	+0.114	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050856 vs CYTH4 — LAML

Explore this scatter interactively →