Regulation of T cell receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of T cell receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCN2, LGALSL, and SQLE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell receptor signaling pathway activity versus RCN2 in GBM (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCN2 →	-0.469	-0.324	<.001	.008	3	5
UCEC	LGALSL →	-0.610	-0.105	.008	.009	3	4
GBM	SQLE →	-0.323	-0.301	.001	.006	3	4
GBM	CD86 →	+0.518	+0.303	.004	.005	3	4
GBM	CD2 →	+0.804	+0.322	<.001	.003	3	4
HNSC	IKZF3 →	+0.738	+0.090	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050856 vs RCN2 — GBM

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