Regulation of T cell receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of T cell receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LYL1, SEC22B, and NAGPA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell receptor signaling pathway activity versus LYL1 in OESOPHAGUS (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	LYL1 →	+0.382	+0.220	.004	.003	3	4
OESOPHAGUS	SEC22B →	+0.724	+0.199	.001	.001	3	4
SOFT_TISSUE	NAGPA →	+0.686	+0.306	.007	<.001	3	4
CNS	IL12A →	+0.731	+0.235	.003	.001	3	3
UPPER_AERODIGESTIVE_TRACT	LAP3 →	-1.121	-0.252	<.001	.002	3	3
OESOPHAGUS	NFATC2 →	+1.064	+0.200	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050856 vs LYL1 — OESOPHAGUS

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